Intrinsic factor antibodies blood test in Chiswick

What the test measures

Intrinsic factor is made by parietal cells in the stomach lining. It binds vitamin B12 from food and carries it to the end of the small intestine, where it is absorbed. In pernicious anaemia the immune system makes antibodies that block intrinsic factor or damage the cells that make it, so B12 cannot be absorbed properly, however much is eaten.

Intrinsic factor antibodies are found in around half of people with pernicious anaemia, but they are rarely found in people without it. That means a positive result strongly supports the diagnosis, while a negative result does not rule it out. UK guidance supports this test when B12 deficiency has been confirmed and the cause is not clear.

The price includes your sample at our Chiswick clinic, analysis at the Randox accredited laboratory, a review of your result with an Omnia practitioner, and a GP feedback report on request.

Who it is for

• You have a low vitamin B12 result and want to find out why.
• You have tiredness, pins and needles, a sore tongue or memory problems along with low B12.
• You have another autoimmune condition, such as thyroid disease or vitiligo, and low B12.
• You have a family history of pernicious anaemia.
• Your gastric parietal cell antibodies were positive and your practitioner suggests a more specific test.

Understanding your result

Your report shows whether intrinsic factor antibodies were detected. A positive finding alongside low B12 strongly supports pernicious anaemia, which usually needs lifelong B12 treatment by injection or, in some cases, high-dose tablets, guided by your GP. A negative result makes it less likely but, because many people with the condition test negative, your practitioner may still discuss other causes or further tests.

A result outside the expected range is a prompt for discussion, not a diagnosis by itself, and it is always read with your B12 level and blood count. People with pernicious anaemia may also need periodic review for related stomach changes, which your GP can arrange.

Preparing for your test

Fasting is not needed. If you have had a B12 injection in the past few days, tell us, as very high B12 levels can interfere with some methods for this antibody test, and we may suggest waiting before testing. Pause biotin supplements for 48 hours beforehand.

Our vitamin B12 tests, including Active B12, show your current levels, and a Full Blood Count shows whether red cells are affected. Intrinsic factor antibodies are also part of Omnia Signature. Find every blood test and price in Chiswick here.

Questions

How much is an intrinsic factor antibodies test in Chiswick?

The intrinsic factor antibodies test costs £89 at Omnia Lifestyle. That covers the blood sample at our Chiswick clinic, analysis at the accredited laboratory, a practitioner review and a GP feedback report on request.

Does a negative result rule out pernicious anaemia?

No. About half of people with pernicious anaemia do not have detectable intrinsic factor antibodies, so a negative result is read with your other findings.

Should I test parietal cell antibodies as well?

Often, yes. Parietal cell antibodies are more sensitive and intrinsic factor antibodies are more specific, so the two together give a clearer picture.

Can I have the test while on B12 injections?

Yes, but recent injections can affect some laboratory methods. Tell us the date of your last injection so we can advise on timing.