Bence Jones protein urine test in Chiswick

What the test measures

Plasma cells in the bone marrow make antibodies, each built from heavy and light protein chains. Normally they make a balanced supply, and only tiny amounts of free light chains reach the urine. When a single group of plasma cells grows abnormally, it can produce large quantities of one type of light chain. Once there is more than the kidneys can reabsorb, these appear in the urine, where they are known as Bence Jones protein.

The test is used in the investigation and monitoring of plasma cell disorders, including monoclonal gammopathy of undetermined significance (MGUS), myeloma and related conditions. It is a specialist test, normally interpreted alongside blood tests such as serum protein electrophoresis and serum free light chains, and is not suitable as a general screen.

The price includes the urine sample you hand in at our Chiswick clinic, analysis at the Randox accredited laboratory, a practitioner review of your result and a GP feedback report on request.

Who it is for

• Your blood tests have shown an abnormal protein band, and your doctor has asked for urine testing.
• You have been diagnosed with MGUS or a plasma cell condition and need monitoring between specialist visits.
• Your urine has shown protein that is not explained by standard tests.
• Your GP or haematologist has requested a Bence Jones protein test.

Understanding your result

A negative result means no Bence Jones protein was detected. A positive result means free light chains of one type are present, and the report may describe the type found. This is a tumour-associated finding that needs specialist interpretation: it can be seen in MGUS, which often never progresses, as well as in myeloma and other conditions, and it cannot diagnose or rule out cancer on its own.

Any positive result should be discussed with your GP or haematologist, who will consider blood tests, symptoms and sometimes imaging. If you have new bone pain, frequent infections or unexplained tiredness, please see your GP rather than relying on a single test. Your result is a prompt for discussion, not a diagnosis.

Preparing for your test

No fasting is needed. An early morning urine sample is usually preferred because it is more concentrated, so please bring your first sample of the day in the sterile container we provide, or tell us if your specialist has asked for a 24-hour collection. Avoid heavy exercise the day before, and let us know if you have a urine infection.

Because light chains are filtered by the kidneys, our kidney function tests and urinalysis add useful context, and the full blood count checks your blood cells. See every blood test and price in Chiswick.

Questions

How much is a Bence Jones protein test in Chiswick?

The Bence Jones Protein (urine) test costs £229 at Omnia Lifestyle in Chiswick. This includes the urine sample, accredited laboratory analysis, a practitioner review and a GP feedback report if requested.

Is this a test for myeloma?

It is one of several tests used when myeloma or related conditions are being investigated or monitored, but it cannot diagnose or exclude myeloma by itself.

Is this the same as a routine urine protein check?

No. Standard dipstick tests mainly detect albumin and often miss light chains. This test is designed specifically to find them.

What is MGUS?

MGUS is a common finding, especially with age, in which plasma cells produce an abnormal protein without causing harm. Most people never develop a related illness, but monitoring is usually recommended.