Anti-LKM antibodies blood test in Chiswick
This blood test looks for anti-LKM (liver kidney microsomal) antibodies, which are linked with type 2 autoimmune hepatitis. It is booked when liver tests are abnormal without an obvious cause, to help investigate possible autoimmune liver disease.
What the test measures
Anti-LKM antibodies are autoantibodies that target enzymes found in the liver and kidney, most commonly a liver enzyme called CYP2D6. The LKM-1 type is the main antibody in type 2 autoimmune hepatitis, a less common form of the condition that more often begins in childhood or young adulthood. Autoimmune hepatitis happens when the immune system attacks the liver, causing ongoing inflammation that can lead to scarring if untreated.
Anti-LKM antibodies are usually tested alongside other autoantibodies, such as antinuclear and smooth muscle antibodies, as well as liver function tests and immunoglobulin levels. They can occasionally be found in people with hepatitis C or after some medicines, so the result is always read in the context of the wider picture.
The price includes your sample at our Chiswick clinic, analysis at the Randox accredited laboratory, a review of your result with an Omnia practitioner, and a GP feedback report on request.
Who it is for
- Your liver function tests have shown raised ALT or AST without a clear reason.
- You have tiredness, joint aches or yellowing of the skin and your liver results are abnormal.
- You have another autoimmune condition and your clinician wants to check for autoimmune liver disease.
- Your GP or a specialist has asked for a liver autoantibody check.
- You have a family history of autoimmune liver disease.
Understanding your result
Your report shows whether anti-LKM antibodies were detected, sometimes with a titre or level. A positive result supports autoimmune hepatitis when it fits with raised liver enzymes and raised IgG, but the diagnosis is usually confirmed by a liver specialist, often with a liver biopsy. A negative result does not rule out other types of autoimmune hepatitis.
A positive result is a prompt for discussion, not a diagnosis, and your practitioner will explain the next steps, including sharing the result with your GP for referral to a liver specialist where appropriate. Yellowing of the skin or eyes, dark urine or confusion need urgent medical attention.
Preparing for your test
You do not need to fast for this antibody test. Keep taking your usual medicines, but tell us about everything you take, including herbal remedies, as some can affect the liver. Mention if you have ever had hepatitis C.
Our liver function tests check ALT, AST and other markers, while the Standard Screen places liver results among wider health markers. Hepatitis C can be checked on our STI testing page. Review every blood test and price in Chiswick.
Questions
How much is an anti-LKM antibodies test in Chiswick?
The anti-LKM antibodies test costs £129 at Omnia Lifestyle. The fee covers your sample in Chiswick, testing at the accredited laboratory, a review with an Omnia practitioner and an optional GP feedback report.
Does a positive result mean I have autoimmune hepatitis?
Not on its own. It supports the diagnosis when liver tests and other findings fit, but a liver specialist confirms it.
What is the difference between type 1 and type 2 autoimmune hepatitis?
Type 1 is more common and linked with antinuclear and smooth muscle antibodies. Type 2 is linked with anti-LKM antibodies and often starts at a younger age.
Can this test be affected by hepatitis C?
Yes. A small number of people with hepatitis C have anti-LKM antibodies, which is why the result is read alongside a hepatitis C test where relevant.
