Genetic prostate cancer risk test in Chiswick

What the test measures

This panel looks at 14 genes where inherited variants have been linked with a raised chance of prostate cancer. It includes HOXB13, a gene with a specific link to prostate cancer, BRCA1 and BRCA2, other DNA repair genes such as ATM, CHEK2, PALB2, NBN and RAD51D, the Lynch syndrome genes, and TP53.

Your DNA is taken from a routine blood sample, so the result describes what you inherited from your parents. It is a different question from a PSA test, which measures a protein made by the prostate at the time of the sample, and it cannot show whether cancer is present.

Your price includes the sample taken at our Chiswick clinic, analysis at the Randox accredited laboratory, a practitioner review of your result and a GP feedback report on request. Results with family implications are best discussed with a genetic counsellor or specialist, and your practitioner can help you find the right route.

Who it is for

• Your father or brother was diagnosed with prostate cancer, particularly before the age of 60.
• Several men on one side of your family have had prostate cancer.
• Your family history includes breast, ovarian or pancreatic cancer alongside prostate cancer.
• A relative carries a known variant in BRCA2 or another gene on this panel.
• You are of Black African or Black Caribbean heritage with a family history and want more information to discuss with a specialist.

Understanding your result

For each gene, the report states whether a pathogenic or likely pathogenic variant was found, whether a variant of uncertain significance was detected, or whether no relevant variant was seen. A pathogenic variant points to a higher lifetime risk, which a urologist or genetics service may use to suggest earlier or regular PSA checks.

If nothing is found, your risk is not reduced to zero. Age, ethnicity and family history all still count, and most prostate cancer is not linked to one inherited gene. Use the result to inform a conversation with a specialist, not as a diagnosis.

Preparing for your test

There is no need to fast or change your routine. Unlike a PSA test, recent exercise, ejaculation or a urine infection do not affect this genetic result. If any relative has had genetic testing, bring their report, and tell us if you have had a bone marrow transplant.

If you would like to check the prostate itself, the Prostate Profile and PSA tests measure prostate-specific antigen. You can also find every blood test and price in Chiswick on our main page.

Questions

How much is a genetic prostate cancer risk test in Chiswick?

It costs £678. That includes your blood sample at our Chiswick clinic, sequencing of 14 genes at the Randox accredited laboratory, a practitioner review and a GP feedback report on request.

How is this different from a PSA test?

A PSA test measures a protein in your blood today and can change over time. This genetic test looks at inherited genes that do not change, and it helps decide whether closer monitoring makes sense.

Can my result affect my children?

Yes. A pathogenic variant has a chance of being passed on to sons and daughters, and some variants raise breast and ovarian cancer risk in women, which is why specialist genetic advice is so helpful.

Does a clear result mean I do not need PSA checks?

No. Your age, ethnicity and family history may still make PSA monitoring sensible. Your practitioner can talk through this with you.