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A CK-MB blood test measures the form of creatine kinase found mostly in heart muscle. It is a specialist marker, usually requested to follow up a heart question with your practitioner rather than as a general screen.
Creatine kinase exists in several forms. CK-MB is the form concentrated in heart muscle, although smaller amounts are also found in skeletal muscle. When heart muscle cells are injured, CK-MB is released into the blood, which is why it was used for many years to assess heart damage. In current NHS practice, troponin has largely replaced it in emergency care because troponin is more specific to the heart.
Important: this is not an emergency test. If you have chest pain, pressure or tightness, pain spreading to the arm, jaw or back, sudden breathlessness, or symptoms of a blood clot, call 999 or go to A&E straight away. Do not book a test.
The price includes the blood sample taken at our Chiswick clinic, analysis at the Randox accredited laboratory, a practitioner review of your result with you, and a GP feedback report on request.
Your report shows your CK-MB value with the laboratory reference range. CK-MB can be raised by heart muscle injury, but it can also rise after heavy exercise, muscle injury or with some long-term muscle and kidney conditions, because skeletal muscle contains a small amount too. A single value is therefore read together with total CK, your history and any symptoms.
A normal result does not rule out heart disease, and a raised result does not confirm it. Any result outside the range is a prompt for discussion with your practitioner, who will refer you to your GP or urgent care where needed.
No fasting is required. Avoid strenuous or unusual exercise for 48 hours beforehand, since skeletal muscle strain can raise CK-MB. Tell us about any recent injury, surgery or heart procedure and the medicines you take. If you develop any of the warning symptoms above before your appointment, call 999 instead of attending.
CK-MB is one of the heart and circulation markers in Omnia Signature, our most comprehensive check. You can also compare every blood test and price in Chiswick.
A CK-MB blood test at Omnia Lifestyle costs £59. This includes the sample at our Chiswick clinic, analysis at the accredited laboratory, a practitioner review of your result and a GP feedback report on request.
No. A suspected heart attack needs emergency assessment in hospital, where troponin and an ECG are used. If you have chest pain or other warning signs, call 999.
Total CK measures all forms of the enzyme, mostly from skeletal muscle. CK-MB is the portion found in greater amounts in heart muscle, so the two are often read side by side.
Intense exercise, muscle injury, some muscle disorders and reduced kidney function can all raise CK-MB. This is why your practitioner considers your history before deciding on any next steps.